Very little is known regarding patients fulfilling clinical DLB criteria with a negative (123I)FP CIT SPECT scan (SCF+) or patients with an abnormal scan not fulfilling clinical DLB criteria (S+CF). In contrast, considerable research has been conducted on PD patients with negative DAT scans, that is, ‘scans without evidence of dopaminergic deficit’. Repeated DAT imaging showed a normal scan up to 4year follow up and this group did not benefit from antiparkinson medication.5 This demonstrates that the causes other than nigrostriatal degeneration can cause parkinsonism, such as, for example, cerebrovascular disease (vascular parkinsonism) and drugs with antidopaminergic activity.6.
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